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There was a significant increase in the level of ACTH, CORT, cortisol, and cortisolDHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisolDHEA/S ratio following 12 weeks of supervised aerobic training, respectively. The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The poten