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Revising the current pharmacovigilance systems to include or expand the range of HTM, and developing an internationally harmonized system to classify and code HTM suitable to the unique characteristics of HTM are critical and overall beneficial. Revising the current pharmacovigilance systems to include or expand the range of HTM, and developing an internationally harmonized system to classify and code HTM suitable to the unique characteristics of HTM are critical and overall beneficial. The evidence-based Japanese integrative m