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3 %, and the negative predictive value was 83.3 %. Furthermore, the level of SNAP-II was 10, and BCL-xL was 3.022 ng/mL as the threshold, and the sensitivity, specificity, positive predictive value, and negative predictive value of septic shock were 93.8 %, 95.2 %, 93.8 %, and 95.2 %, respectively. BCL-xL is associated with the progression of sepsis. The combination of BCL-xL and SNAP-II could be early predicte the severity of the disease. BCL-xL is associated with the progression of sepsis. The combination of BCL-xL and SNAP-II