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RFHE was shown to be significantly correlated with lowering the level of MDA, TNF-α, IL-6 and CRP of diabetic rats. Moreover, RFHE significantly elevated the GSH and TAS serum levels in diabetic rats when compared with STZ group. RFHE might have anti-diabetic properties; this outcome may be mediated by high antioxidant and anti-inflammatory effects. RFHE might have anti-diabetic properties; this outcome may be mediated by high antioxidant and anti-inflammatory effects. The mechanisms underlying the relations between diabetes self-care b