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Our analysis of the relationship between unmet mental health care needs and substance use across various geographic areas involved logistic regression models with interaction terms. Unmet mental health needs in people with depression were associated with increased use of marijuana (OR=132, 95% CI 108-164), illicit drugs (OR=175, 95% CI 119-258), and prescription drugs (OR=189, 95% CI 119-30, a pattern that held constant a