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INTRODUCTION Pathophysiology changes associated with pleural effusion, its drainage, and factors governing symptom response are poorly understood. Our objective was to determine thei. Effect of pleural effusion (and its drainage) on the cardiorespiratory, functional, and diaphragmatic parameters;ii. Proportion and characteristics of patients with breathlessness relief post-drainage. METHODS Prospectively-enrolled patients with symptomatic pleural effusions were assessed pre- and at 24-36 h post-therapeutic drainag