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The potential roles of these diagnostic genes are also illuminated by GSEA. Besides these findings, genes potentially contributing to diagnosis showed a strong correlation with drug sensitivity. To conclude, a method for diagnosing renal fibrosis in the form of a nomogram was developed. Biomarkers COL4A2, CXCL1, TIMP1, VCAM1, and VEGFA show promise in identifying renal fibrosis in both serum and tissue samples. COL4A2, CXCL1, TIMP1, VCAM1, a