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© 2020 The Authors. Cancer Science published by John Wiley Sons Australia, Ltd on behalf of Japanese Cancer Association.In this study, we investigated the design and construct of a chitosan-based targeted gene delivery system and evaluated its function. To this end, chitosan-folic acid/pDNA (CA-FA/pDNA) nanoparticles were prepared in different formulations using the ion gelation method. All the synthesized nanoparticles were characterized using FTIR, TEM, SEM and DLS analysis. Moreover, the effects of molecular weight (MW) of chi
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