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Goal of this review is to provide an overview of the key notions which need to be mastered and of the state of the art of this rapidly evolving field at the interface between chemistry and physics. In cases of drunk-driving, allegations that alcohol has been consumed after the incident, are proved by analyzing congener alcohols in the blood sample. 1-Propanol, one of the main congener compounds, was tested, whether it is also endogenously formed when a person has consumed alcoholic beverages. Eleven male and 13 female volunteers consume