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This study aimed to explore the roles of ERCC1/XPF gene polymorphisms in the occurrence of breast cancer in the Uygur and Han ethnic groups in Xinjiang, China. Single nucleotide polymorphisms (SNPs) were detected by TaqMan real-time PCR. The rs11615 GA and rs2276466 CG variant frequencies were higher in Uygur patients with breast cancer than in Han patients, while the frequency of rs2298881 CA was higher in Han patients. We found that rs2298881 CA (CA vs. CC OR = 0.35, 95% CI = 0.20-0.60; AA vs. CC OR = 0.13, 95% CI = 0.