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Over the course of DNA ****tion, DNA lesions, transcriptional intermediates and protein-DNA complexes can impair the progression of ****tion forks, thus resulting in ****tion stress. Failure to maintain ****tion fork integrity in response to ****tion stress leads to genomic instability and predisposes to the development of cancer and other genetic disorders. Multiple DNA damage and repair pathways have evolved to allow completion of DNA ****tion following ****tion stress, thus preserving genomic integrity. One of t