https://www.selleckchem.com/products/dc661.html
Site-specific conjugation of double-stranded DNA using antibodies enables the development of unique applications for antibody drug conjugates utilizing recent advances in nucleic acid medicines. Here, we describe a novel method to conjugate a camelid-derived single domain VHH antibody with arbitrarily-sized double-stranded DNA by PCR. Cysteine in anti-human EGFR VHH were replaced by alanine, and an unpaired cysteine was introduced at the carboxyl-terminus. These modifications enabled site-specific labeling with a maleimide-modified DNA ol
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