https://www.selleckchem.com/pr....oducts/Vorinostat-sa
The degradation of the xenobiotic phthalic acid esters by microorganisms is initiated by the hydrolysis to the respective alcohols and ortho-phthalate (phthalate). In aerobic bacteria and fungi oxygenases are involved in the conversion of phthalate to protocatechuate, the substrate for ring cleaving dioxygenases. In contrast, anaerobic bacteria activate phthalate to the extremely unstable phthaloyl-CoA that is decarboxylated by oxygen-sensitive UbiD-like phthaloyl-CoA decarboxylase (PCD) to the central benzoyl-CoA intermediate.
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