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Heel blood sampling of newborns plays an important role in the diagnosis of neonatal hypothyroidism, phenylketonuria, and other inherited metabolic diseases. Embracing breast milk sucking (EBMS) can increase the newborn's sense of security and can relieve pain. The purpose of the present study was to explore the effect of EBMS on alleviating the pain of neonatal heel blood sampling. A total of 96 neonates undergoing heel blood screening were selected from June 2019 to June 2020, and were randomly divided into 2 groups (n=48 in each group