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Importantly, the results also show that HFD also provoked a cerebral overload in reactive oxygen species such as OH•, H2O2 and O 2 ∙ - as well as brain inflammation assessed by the overproduction of cytokines such as IL-1β and IL-6. Interestingly, all neurobehavioral changes and all the biochemical and molecular disturbances were abolished in HFD-fed rats treated with CDE. Our results provide clear evidence that obesity and depression as well as anxiety are finely correlated and that M. recutita's decoction may prove to be a potential th
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