https://map4k-receptor.com
Mutations to the RNA spliceosome complex's constituent core or accessory elements affect the characterization of splicing sites, consequently altering their function. These modifications to gene expression in cancer cells can induce disruptions in cancer-associated gene expression and lead to the generation of novel mRNA molecules, some of which play critical roles in disease progression and may be targeted therapeutically. Further investigation has revealed that hematopoietic cells with mutations in splicing factors depend on the expression of the remaining
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