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To investigate the connection between mutant and clinicopathological characteristics in therapy-naïve synchronous metastatic colorectal cancer (mCRC) in Chinese populations when compared with all wild type ( wild type). A total of 200 patients with therapy-naïve synchronous mCRC (TNM stage TanyNanyM1) were retrospectively collected as study objects. Primary tumor tissues from 200 mCRC patients were analyzed through next-generation sequencing panel to assess the mutated regions of . The distribution frequency of gene mutation in our study