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001). In addition, patients in Q4 of the fluid balance had a significantly longer LOS in the ICU, as well as a higher incidence of AKI and ICU mortality. In a multivariate analysis, Q4 of the fluid balance was independently associated with prolonged mechanical ventilation (OR 4.9, CI 2.9-8.4, 0.001) and prolonged LOS in the ICU (OR 11.3 CI 6.1-20,9, 0.001), but not with the incidence of AKI or ICU mortality. Perioperative fluid administration in cardiac surgery patients was independently associated with prolonged mechanical v