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Title: Door Handle Emergency Repair: A Comprehensive Guide When it concerns home maintenance, door handles are typically overlooked until an emergency emerges. A malfunctioning door handle can annoy locals and compromise security. Whether it's a basic jam or a total breakdown, understanding how to address door handle issues can conserve time and cash. This article supplies an extensive overview of common door handle problems, emergency repair te

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vity in children. Cite this article Bone Joint J 2021;103-B(2)405-410. Echocardiography is commonly used in hip fracture patients to evaluate perioperative cardiac risk. However, echocardiography that delays surgical repair may be harmful. The objective of this study was to compare surgical wait times, mortality, length of stay (LOS), and healthcare costs for similar hip fracture patients evaluated with and without preoperative echocardiograms. A population-based, matched cohort study of all hip fracture patients (aged over 45 years) in O

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We examined relationships between pattern of team sport participation during the transition from adolescence to young adulthood (ie, non-participants, initiators, discontinuers, sustainers) and indicators of mental health. Data on team sport participation and mental health from high school to young adulthood were drawn from the longitudinal NDIT study. After controlling for demographics, physical activity, and previous mental health, one-way MANCOVA and ANCOVAs indicated that pattern of team sport particip

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In recent years, a number of epidemiological studies have demonstrated that exposure to air pollution is associated with several adverse outcomes, such as acute lower respiratory infections, chronic obstructive pulmonary disease, asthma, cardiovascular diseases, and lung cancer among other serious diseases. Air pollutants such as sulfur oxides, nitrogen oxides, carbon monoxide and dioxide, particulate matter (PM), ozone and volatile organic compounds (VOCs) are commonly found at high levels in big cities and/or in the vicinity of differen

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ERRB2 (formerly HER2)-positive advanced breast cancer (ABC) remains typically incurable with optimal treatment undefined in later lines of therapy. The chimeric antibody margetuximab shares ERBB2 specificity with trastuzumab but incorporates an engineered Fc region to increase immune activation. To compare the clinical efficacy of margetuximab vs trastuzumab, each with chemotherapy, in patients with pretreated ERBB2-positive ABC. The SOPHIA phase 3 randomized open-label trial of margetuximab plus chemotherapy vs trastuz

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Background Rheumatic heart disease (RHD) is a neglected disease affecting 33 million people, mainly in low and middle income countries. Yet very few large trials or registries have been conducted in this population. The INVICTUS program of research in RHD consists of a randomized-controlled trial (RCT) of 4500 patients comparing rivaroxaban with vitamin K antagonists (VKA) in patients with RHD and atrial fibrillation (AF), a registry of 17,000 patients to document the contemporary clinical course of patients with RHD, including a focu

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Total Organic Carbon (TOC) concentrations in stream waters from peat-covered catchments have increased over the last 15-25 years, resulting in large-scale brownification of lakes and rivers in high latitudes. While this increase has primarily been attributed to decreased acid deposition and climatic warming in most regions, we studied whether peatland drainage in forested catchments has contributed to the increasing TOC concentrations. We analysed the spatial variability of average TOC concentrations from a total of 133 peatland dominat

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De-escalation of bone-targeted agents is cost-effective from the Canadian public payer's perspective.Despite the rapid development of two-dimensional covalent organic frameworks (2D COFs) in recent years, it remains a great challenge to synthesize highly crystalline COF materials. Here, a CNC-assisted approach was adopted to synthesize high crystallinity COF materials. A series of 2D COF films were synthesized at the air-water interface by using cellulose nanocrystals (CNCs) as the template. The occurrence of Schiff reactions based on t

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05). Survival analysis showed that the DFS of BC patients with reduced FOXP3+ Tregs was significantly better than that of patients with elevated FOXP3+ Tregs (P = 0.029). The sTILs count and MPI were significantly higher in primary tumors than lymph nodes (P less then 0.05). Conclusion After NAC, the reduced infiltration of FOXP3+ Tregs was correlated with an improvement in DFS in BC patients. Changes in the number of FOXP3+ Tregs and the MPI may be used as prognostic markers for BC patients. Copyright © 2020 Wang, Xiang, Yu, Hu, C