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Infections are common and are a major cause of morbidity and mortality during treatment of childhood leukemia. We evaluated the cost effectiveness of levofloxacin antibiotic prophylaxis, compared to no prophylaxis, in children receiving chemotherapy for acute myeloid leukemia (AML) or relapsed acute lymphoblastic leukemia (ALL). A cost-utility analysis was conducted from the perspective of the single-payer health care system using a lifetime horizon. A comprehensive literature review identified available evidence for effectiveness, safet

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OBJECTIVE We compared the outcomes in soft tissue sarcoma (STS) treated with olaratumab and doxorubicin (OD) versus doxorubicin, ifosfamide, and mesna (AIM) to assess whether OD could supersede AIM in STS therapy. METHODS A single-institution, retrospective study of STS treated for advanced disease with OD or AIM in 2013 to 2017 was conducted. Demographic and clinical parameters were compared by Fisher's exact test. Kaplan-Meier and Cox analyses examined progression-free survival (PFS) and overall survival (OS). Adverse events were comp

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The present study aimed to explore the etiological relationship between fetal abnormalities and copy number variations (CNVs) with the aim of intervening and preventing the birth of children with birth defects in time. Samples of 913 fetuses with puncture indications were collected from January 2017 to December 2019. Karyotype analysis and CNV sequencing (CNV-seq) testing was performed for fetuses with ultrasonic abnormalities, a high risk of Down's syndrome and an adverse birth history. All cases were followed up. In total, 123 cases (

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Race-matched healthy individuals from the same geographic regions were used as controls for each cohort. Higher levels of gene expression of and were observed during VOC. Furthermore, plasma activity of PADI4 was higher in acute VOC when compared to healthy individuals. These results demonstrate that NETosis regulators are modulated during acute VOC, and pave the way for studies of inhibition as a therapeutic strategy for acute VOC in SCD. Higher levels of gene expression of PADI4 and ELANE were observed during VOC. Furthermore, plasma

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Similarly, compared with the baseline data at Kecha, the SWC practices reduced the surface runoff and SY by about 40% and 43%, respectively, corresponding to about 65-78% of the total changes brought by changes in land use/land cover and climate variability. Hence, combining the two approaches helped reasonably estimate the reduction of surface runoff and SY due to SWC practices by about 28-40% and about 43-68%, respectively, implying that SWC practices had a considerably greater effect on SY than surface runoff. The study further revea

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167) as well as mean (p = 0.903), peak (p = 0.294), and minimum (p = 0.103) power relative to fat-free mass between groups. The findings suggest that individuals living with obesity work at a higher relative drop load when utilizing a percentage of body mass; however, a reduced cycling cadence results in similar total work volume throughout SIT. The findings suggest that individuals living with obesity work at a higher relative drop load when utilizing a percentage of body mass; however, a reduced cycling cadence results in similar total work volume through

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c economic needs. However, both of these highly gendered and devalued jobs may negatively affect health and wellbeing of women. Benzopyrene is rapidly incorporated and metabolized, and induces oxidative stress and activation of antioxidant enzymes, and CYP450 and GST metabolizing enzymes in Ulva lactuca. To analyze absorption and metabolism of benzo[a]pyrene (BaP) in Ulva lactuca, the alga was cultivated with 5µM of BaP for 72h. In the culture medium, BaP level rapidly decreased reaching a minimal level at 12h and, in the alga, BaP

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9% in the low-risk group, 24.0% in the intermediate-risk group, 49.7% in the high-risk group and 40.0% in the very high-risk group. Harrell's C-index for discriminating between those with and without a significant reduction in estimated glomerular filtration rate 1-12months after robotic-assisted partial nephrectomy was 0.73 (95% confidence interval 0.68-0.78). The risk groups proposed by the Martini nomogram are accurate in predicting those at higher risk for a 25% decline in postoperative estimated glomerular filtration

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In Jordan, women experience considerable levels of different types of violence. The emerging data from different countries indicate that intimate partner violence (IPV) has intensified since the COVID-19 outbreak. The main purpose of the current study is to find out whether there is any difference in the incidence of IPV during and before the COVID-19 pandemic quarantine and whether any sociodemographical factors are related to the incidence of IPV against pregnant women during quarantine. A cross-sectional, correlational design was in

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This resulted in restoration of capsule accumulation in vitro and virulence (in intravenous or subcutaneous inoculation) in vivo. To test for additional pXO2-based genes involved in capsule production, we cloned the pagAprom-capA-E into the chromosome of VollumΔpXO2, which restored capsule accumulation. These results indicate that of the pXO2 genes, only capA-E and acpA are required for capsule production.Biological detergents are used in research laboratories, to extract or solubilize proteins from cell membranes. In order