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Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary content and rhythmicity regulate the diurnally shifting SI epithelial cell (SIEC) transcriptional landscape through modulation of the SI microbiome. We exemplify this concept with SIEC major histocompatibility complex (MHC) class II, which is diu

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tients with CPP after PID, the therapeutic effect is superior to simple ibuprofen sustained-release capsule. Acupuncture combined with ibuprofen sustained-release capsule can effectively improve the symptoms, signs and quality of life in patients with CPP after PID, the therapeutic effect is superior to simple ibuprofen sustained-release capsule. To verify the clinical effect of acupuncture on knee osteoarthritis (KOA). Forty-two patients with KOA were randomly divided into an acupuncture group (21 cases, 1 case dropped off) and a sham

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Accurate source localization from electroencephalography (EEG) requires electrode co-registration to brain anatomy, a process that depends on precise measurement of 3D scalp locations. Stylus digitizers and camera-based scanners for such measurements require the subject to remain still and therefore are not ideal for young children or those with movement disorders. Motion capture accurately measures electrode position in one frame but marker placement adds significant setup time, particularly in high-density EEG. We developed an algor

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Worldwide cardiovascular diseases such as stroke and heart disease are the leading cause of mortality. While guidewire/catheter-based minimally invasive surgery is used to treat a variety of cardiovascular disorders, existing passive guidewires and catheters suffer from several limitations such as low steerability and vessel access through complex geometry of vasculatures and imaging-related accumulation of radiation to both patients and operating surgeons. To address these limitations, magnetic soft continuum robots (MSCRs) in the form

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results. Furthermore, CS-CH-PLGA-NPs were found to be more significant (p less then 0.001) for the treatment of seizure threshold rodent models, that is, increasing current electroshock and pentylenetetrazole-induced seizures. A significant role of CS-CH-PLGA-NPs was observed, that is, p less then 0.001, for the enhancement of brain bioavailability and the treatment of epilepsy.The cardiac expression of the mitochondrial uncoupling protein (UCP)-2 is increased in patients with heart failure. However, the underlying causes as well as

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Climate parameter influences on radial growth were investigated by correlating detrended growth index chronologies with growth response indices for drought years 2003, 2012, 2015, and 2018, using bootstrapped analysis. C. libani's radial growth was positively linked to high water availability during late winter and spring; a similar relationship held for P. abies in February and summer, and for P.

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Thus, we also investigate various fusion methods that combine the opinion of the committee at different levels maximum voting, product, decision template, Bayes, Dempster-Shafer, etc. The proposed method is evaluated using ICPR-2014 data which consists of more images than some previous datasets ICPR-2012 and demonstrate state-of-the-art performance. To check the effectiveness of the proposed methodology for other related datasets, we test our methodology with newly compiled large-scale HEp-2 dataset with 63K cell images and de

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Best Bean to Cup Coffee Machines: A Comprehensive Guide In recent years, the coffee world has actually seen a substantial shift toward convenience and quality. Amongst the myriad of coffee machines available, bean-to-cup coffee machines have actually gotten immense popularity for their ability to provide freshly ground coffee with very little effort. This short article explores the best bean-to-cup coffee machines available on the marketplace, offering insights into their features, benefits, and some often asked questio