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Moreover, the model predicted that the higher pressures (P 1.5 MPa) would intensify the inhibition of N2 production via denitrification and result in an accumulation of ammonia in the sediment along with a decrease in dissolved oxygen. The results imply that increased hydrostatic pressure caused by dam constructions may have a strong effect on microbial nitrogen conversion, and that this may result in lower nitrogen removal.The disposal and reuse of cephalosporin mycelia dregs (CMDs) pose a great challenge to the biopharma industry,